Single-Use Technologies V: Building the Future

An ECI Conference Series

March 20-23, 2022
Marseille, France

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About This Conference

Single-Use Technologies V: Building the Future is the fifth event of an ECI conference series started in 2015 and unique in its aim – to advance knowledge in the fundamental science and engineering underpinning Single-Use Technology (SUT).

The conference will be a 4-day event (March 20 to 23, 2020) in Marseille, France, and will target 100-120 attendees, face to face. The conference will have speakers and attendees from industry and academia, single-use final product (e.g. bags, assemblies) manufacturers, film/resin manufacturers as well as keynote speakers from the biopharmaceutical industry, experts in polymers/materials science and manufacturers of novel biomedical devices.

The fifth series of this conference will build on the success of the previous three in-person editions and a successful virtual conference held in May 2021. The fifth edition aims to focus on the role of SUT during the pandemic, including lessons learnt in the process, regulatory and technical aspects and how the industry has changed post-pandemic. Other topics will include sustainability and the role of SUT in continuous processing for established and emerging applications, advances in sensors, soft sensors and their integration within SUT, modelling and optimization tools for assessment of SUT in production facilities. 

This conference brings together a multidisciplinary community interested in collaborating openly towards the advancement and adoption of single-use technology in the bioprocessing industry. The organizing committee welcomes the submission of scientific work that is novel and of high quality.

Confirmed Keynote Speakers

Uwe Gottschalk

Uwe Gottschalk is Chief Scientific Officer (CSO) at Lonza since July 2017. Between 2014 and 2017 he served as a Chief Technology Officer where he established and led the global Research and Technology organisation of Lonza Pharma/Biotech.

Before joining Lonza he served as Group Vice President at Sartorius
Stedim Biotech between 2004 and 2014 with a global responsibility for
all bioseparation-related process technology. He worked in different
capacities for Bayer Health Care from 1991 to 2004, overseeing the process development and manufacturing of biopharmaceutical products such as monoclonal antibodies and other recombinant proteins.

Uwe earned his M.Sc and PhD in Chemistry at the University of Münster, Germany and Nottingham, UK, delivering his dissertation on drug targeting with monoclonal antibodies. He has written extensively in the areas of downstream processing, industrial biotechnology and somatic gene therapy. In academia, Dr. Gottschalk is currently Head Lecturer at the University of Duisburg-Essen (Germany) and also lectured at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Lausanne (Switzerland).

Dr.Gottschalk was board member of the VBU Association of German Biotech Companies between 2006 and 2010. He sits on the editorial advisory boards of Pharmaceutical Bioprocessing, Genetic Engineering News and BioPharm International. He is honorary member of the Society for BioChromatography and Nanoseparations, member of the Management Pool at the Institut of Marketing, University of St.Gallen (HSG) and member of the American Chemical Society (ACS).


Hans-Josef Endres

Director of the Institute for Plastics and Circularity, Leibniz University Hannover

Educational background:  
■ Dipl.-Ing. graduate of the Ruhr University Bochum, 1991,  mechanical engineering, strong focus on material research 
■ PhD (Dr.-Ing.) received from University of Bochum, 1995  

Professional experience and activities: 
■ 9 years of employment with industrial companies including a position as  departmental director at Thyssen-Krupp, overseeing a staff of 230
■ 1999: Professor at Hannover University of Applied Sciences & Arts
■ 2011: Director of the IfBB – Institute for Bioplastics and Biocomposites
■ 2012: Head of Application Center for Wood Fiber Research, Fraunhofer Wilhelm-Klauditz-Institut WKI 
■ 2019: Professor at the Leibniz University of Hannover, Institute of Plastics and Circular Economy 

Achievements:  
■ engaged in bioplastics and plastics recycling for more than 25 years; 
■ established the IfBB – Institute for Bioplastics and Biocomposites; 
■ established a Fraunhofer Application Center for Wood Fiber and Composite Research;
■ authored various publications and received numerous honors and prizes for his research  in sustainability of plastics

Conference Organization

Conference Chairs

Magali Barbaroux, Sartorius
Martina Micheletti, University College London

Steering Committee for Single-Use Technologies V

Ruben Carbonell, North Carolina State University

Weibing Ding, GSK

Regine Eibl-Schindler, Zurich University of Applied Sciences

Beth Junker, BioProcess Advantage LLC

Sally Kline, Genentech-Roche

Gary Lye, University College London

Ekta Mahajan, Genentech-Roche

Robert Repetto, Pfizer

Conference Outline

Session 1 – Single-use in pandemic times – lessons learnt and future outlook

Co-chairs: Yvonne Genzel (Max Planck Institute), Ekta Mahajan (Roche Genentech), Jeff Carter (Cytiva), tbd

This session accepts papers on the impact of the pandemic on the SUT world, with both a retrospective view to gain lessons learnt, and a prospective view to how the industry may be better prepared for a subsequent major upset.  The session aims to address topics that are central to managing SUT, such as maintaining industry flexible standards, addressing benefits of standardization, and implementing cost-effective risk-mitigation solutions to secure future SUT supply, all while continuing to meet global regulatory requirements. Case studies are welcome on the role of SUT in manufacturing of key therapeutics and vaccines during the pandemic. These case studies may highlight how these technologies have enabled rapid vaccine manufacturing response, as well as the challenges encountered e.g., due to supply constraints. Papers are invited which reflect on post-pandemic world solutions to ensure productivity and to build capacity at speed, while looking forward to anticipating future major industry-changing disruptions and novel risk mitigation strategies to support increase in demand without negative implications to the industry.

Session 2 – Sensors and their integration with single-use technology

Co-Chairs:  Torsten Mayr (TU Graz) and Jim Furey (PendoTECH)

Sensors are critical to biopharmaceutical manufacturing for process control, data acquisition, PAT continuous processing that leads to a more efficient manufacturing processes. Single use processes require sensors that are pre-sterilized, ready to use without any calibration and can be disposed of after the process. Ideally, these sensors are suitable for batch and continuous processes. The scope of this session is to give insights in new developments and advances of sensors for single-use, efforts towards integration in single-use devices, new parameters, miniaturisations, soft sensors, reliability, robustness, and validation approaches for use in a GMP process.

Session 3 – Single-Use advantages in continuous and connected processing

Co-chairs: Peter Levison (Pall Biotech) and Mark Brower (Merck)

This session will address how SUT have facilitated and supported the development of continuous operation processes for biopharmaceuticals production. Focus areas will include:

  • The economic case for SUT in continuous processing, for both upstream and downstream operations and end-to-end processing
  • Regulatory and validation considerations and challenges for SUT in continuous processes
  • Consideration of ICH Guidelines on Continuous Manufacturing to accommodate large molecules
  • Innovative solutions in SUT for continuous processes
  • Scale-down approaches for SUT continuous processes 
  • How connected is connected and how continuous is continuous?

Session 4 – Single-use adoption in emerging applications

Co-chairs: Qasim Rafiq (UCL) and Diego Schmidhalter (Lonza)

This session will focus on the use of single-use technologies in bioprocesses for emerging applications, including vaccines, cell and gene therapy, industrial biotechnology and antibody-drug conjugates. The session will include case studies showcasing the adoption and application of single-use technologies across these bioprocessing sectors, with a focus on the challenges and opportunities associated with their integration. In some instances, these sectors rely exclusively on single-use technologies (e.g. patient-specific gene therapies), and this session will highlight how single-use technology can accelerate the quest for speed and flexibility in this space. This session will provide an evaluation of how single-use technologies have been implemented, with a specific focus on upstream/downstream process unit operations and end-to-end bioprocessing. It will also explore the future requirements and perspectives to ensure successful integration of single-use technologies for the manufacture of 21st century biological products.

Session 5 – Single use and sustainability

Co-chairs : Kristi Budzinski (Roche Genentech) and Nelly Montenay (Sartorius)

This session will focus on the integration of environmental sustainability priorities into Single Use Technologies from the design phase through the end-of-life. It will include case studies on a SUS bioprocess environmental assessment with tools such as LCA (Life Cycle Assessment, but not limited to) polymer resin choice and assembly design as well as end-of-life treatment options. Environmental hot spots will be identified through these assessments and then the session will focus on opportunities in these areas to reduce impact. The session will explore design choices such as polymer formulation, product functionality and design to integrate sustainable criteria in SUT development. Reusability options and shelf-life extension during the use phase will be discussed as opportunities to reduce impact. It will also explore end of life management options and the challenge of segregating packaging, and non-contaminated versus contaminated components.

Call for Abstracts

One-page abstracts should be submitted as soon as possible and no later than the deadlines noted below. The abstract should include both the significance of the research as well as results that will be discussed in order to allow a scientific assessment of the work by the organizers. Please indicate the most relevant session topic for which you are submitting your abstract and whether the abstract should be considered for an oral or poster presentation.

The specific topics are (sessions are described above):

Session 1 – Single-use in pandemic times – lessons learnt and future outlook

Session 2 – Sensors and their integration with single-use technology

Session 3 – Single-Use advantages in continuous and connected processing

Session 4 – Single-use adoption in emerging applications

Session 5 – Single use and sustainability

Only a limited number of oral presentation slots are available. Thus all submissions for oral sessions will be considered for both oral and poster presentation.

All abstracts should be submitted electronically and submissions must follow the template provided at this link.

Deadline for abstracts for oral and poster presentations:                  September 30, 2021

Awards will be presented for the overall best poster and for the top three student posters.

https://ssl.linklings.net/conferences/singleusetech/

Please prepare your abstract according to this template: docx or doc.

Sponsors

Bill and Melinda Gates Foundation

Venue Information

Marseille

Marseille is the oldest city in France. A Greek settlement, founded in the 7th century BC, then called Massilia, Marseille was seized by the Romans in 49 BC.  It became the “Gateway to the West” for most Oriental trade. France’s largest port and lively second largest city has close links with the Middle East and North Africa.  It claims 300 days of sunshine per year.

Narrow stepped streets, quiet squares, and fine 18th century facades contrast with the bustle of Boulevard Canebiére and the Cité Radieuse, Le Corbusier’s postwar radical housing complex.  The old harbor now only handles small boats, but its daily fish market is renowned. The intense smell of fish and salty sea air contribute to making this experience engaging to the senses.  Large cruise ships dock at Léon Gourret Pier, approximately five kilometers north.

The defining symbol of Marseille towers on a hilltop 154 meters above the city, with the gilded statue of the Virgin Mary stretching skywards.  The views are simply stunning. One can either take a shuttle for convenience or embark on a just-under-an-hour-long hike up from the old port.  

Saint Victor Abbey is Marseille’s oldest church.  The abbey was built by the graves of Marseille’s first martyrs.  Throughout history, the building was used as a church, prison, warehouse and barracks.

Marseille has many excellent museums.  Those in the old harbor include the Roman Docks Museum, situated on the site of a Roman docks warehouse discovered after World War II.  It contains a range of impressive artefacts discovered during the reconstruction of the Old Harbor. One of its primary attractions are the “dolia” – large ceramic containers once used to store oils and wines.  

The Marseille History Museum is an interesting and well-visited museum with historical and archeological artefacts dating back to the city’s founding times.   The Palais Longchamp is an extraordinary, majestic building right in the middle of the city that takes you years back in time with its ornamental staircases and large fountains.  The building houses the Musée des Beaux-Arts and the Natural History Museum.

Splendidly situated on a hillside above the Vieux Port, this colorful neighborhood is the historic center and cultural heart of Marseille. Le Panier is Marseille’s oldest quarter, inhabited since antiquity when the ancient Greeks settled here in 600 BC. With its steep, narrow winding streets and quaint pastel buildings, this quarter offers a glimpse into the charming personality of Marseilles. Once a working class neighborhood, Le Panier is now gentrified, but still has a fascinating multiethnic and artistic character. You will find plenty of authentic Algerian cuisine, local artisan boutiques, gourmet food shops, and art galleries. This quarter is also a residential neighborhood, and the typical houses with shuttered window and lines of laundry provide evidence of the families who live there.

The Marseille Tourism website, www.marseille-tourisme.com/en/, provides a wealth of information about this vibrant city and it is highly recommended that you check it out.

InterContinental Marseille – Hotel Dieu

Housed in a listed historical monument, having served as the city’s primary hospital for over eight hundred years, this elegant hotel opened in 2013.  Offering an inimitable view of Marseille, the InterContinental Marseille-Hotel Dieu, is a most majestic encounter with the city and Provence. It is perfectly located, overlooking the Vieux Port, right beside the oldest district in Marseille known as the Panier.  The hotel boasts a very beautiful terrace from which one can admire the Vieux Port.  

The remains of a 12th century chapel are buried beneath the hotel’s gardens. A Roman mosaic dating from the 1st century A.D. can be seen in the Espace Culturel (on the ground floor).  A sustainable pilot project, the InterContinental Marseille – Hotel Dieu is the first hotel ever to be restructured subject to an environmental quality certification. This certification requires scrupulous monitoring of stringent specifications, especially in the choice of building materials, energy and water management, visual comfort, acoustics, and in the quality of air and water.

Sponsor Information

 Package A: $2,500 

• Half-page ad in program 
• Name of Company on Sponsor List in Program 
• Company Logo displayed on screen between sessions 

Package B: $5,000 

• Full page ad in program 
• Sponsor a Coffee Break including poster display 
• Name of Company on Sponsor List in Program 
• Company logo & link on conference website 
• Company Logo displayed on screen between sessions 

Package C: $7,500 

• Sponsor a Scientific Session or Workshop 
• Full page ad in program 
• Name of Company on Sponsor List in Program 
• Company logo & link on conference website 
• Company Logo displayed on screen between sessions 

Package D: $10,000 

• Full page ad in program 
• Company information packet available in attendees’ registration materials 
• Name of Company on Sponsor List in Program 
• Company logo & link on conference website 
• Company Logo displayed on screen between sessions 

Kevin Korpics (kevin@engconfintl.org) (+1-212-514-6760) may be contacted for invoicing and other questions. Please make checks payable to: 

Engineering Conferences International 
Attn: Single Use Technology III Conference 
32 Broadway, Suite 314 
New York, NY 10004 

Payment can also be made via wire transfer or credit card. 

You must reference your company name and the conference title “Single Use Technology IV” or code (20-AS) so the contribution can be identified. Thank you in advance. 

Please note that none of the sponsor packages include any free or discounted registrations for attendees from sponsor companies.

Previous Conferences in This Series

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications
October 18-21, 2015
Leesburg, VA, USA
Conference Chairs:
Ekta Mahajan, Genentech, Inc., USA
Gary Lye, Department of Biochemical Engineering, University College London, UK

Single-Use Technologies II: Bridging Polymer Science to Biotechnology Applications 
May 7-10, 2017
Tomar, Portugal
Conference Chairs:
Ekta Mahajan, Genentech, Inc., USA
Gary Lye, Department of Biochemical Engineering, University College London, UK
Regine Eibl, Zurich University of Applied Science, Switzerland

Single-Use Technologies III: Scientific and Technical Advancements
September 23-26, 2018
Snowbird, Utah, USA
Conference Chairs:
Weibing Ding, Amgen, USA
Martina Micheletti, University College London, UK
Robert Repetto, Pfizer, USA

Single-Use Technologies IV: Building the Future Webinar
May 20, May 25, June 1, 2021
Conference Chairs:
Magali Barbaroux, Sartorius, France;
Weibing Ding, GSK
Martina Micheletti, University College London

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Engineering Conferences International (ECI) is a not-for-profit, global engineering conferences program, originally established in 1962 that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

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