Nanotechnology in Medicine III: Enabling Next Generation Therapies

An ECI Conference Series

POSTPONED

If you made a pre or post conference registration at the Grand Hotel San Michele, please contact them directly to cancel. We, as chairs, will continue to have our regularly scheduled conference planning calls and will be in touch with those of you who are already a part of the program, those who wish to update abstracts, those who still wish to submit abstracts, and those on our mailing list. We ask for your patience as all of us are, as first priority, dealing with the health and safety of our families and ourselves.

Sincerely,
Nanotechnology in Medicine III Conference Chairs
Milica Radisic, University of Toronto
Victor Shahin, University of Münster

and

Nanotechnology in Medicine III Organizing Committee
Millicent Sullivan, University of Delaware
Josué Sznitman, Technion-Israel Institute of Technology
Joye Bramble, Eisai Pharmaceuticals

May 2022 (TBA)
Grand Hotel San Michele
Calabria, Italy

Abstract Submission
(Coming Soon)

About This Conference

Following the success of the first three ECI conferences on nanotechnology in biology and medicine (Nanotechnology for the Study of Cellular and Molecular Interactions in 2009; Nanotechnology in Medicine: From Molecules to Humans in 2016) and Nanotechnology in Medicine II:  Bridging Translational in vitro and in vivo Interfaces in (2018), we set out to continue the series in Nanotechnology in Medicine with this fourth edition.

Nanotechnology promises to transform the way we treat and detect diseases. A few examples include systemically injectable nanoparticles for the targeted delivery of multiple therapeutic and contrast agents, advanced platforms and nanotechnologies that enable us to detect disease rapidly and understand molecular interactions needed to develop new therapeutics.  

Despite the enormous promise, only a few therapies have reached the clinic. Less than 10% of systemically injected nanoparticles reach the intended target despite very robust targeting efforts. The fundamental understanding of the factors that lead to decreased bioavailability, such as serum protein adhesion, nanoparticle aggregation, permeability across tissue barriers and transfer through the intracellular and extracellular routes are limited. They depend on many factors including chemistry of the nanoparticles, aggregation and mechanical properties of the environment they are applied to.  

Recent advances in stem cell biology and microfabrication, enable us to develop on-chip models of human tissues. With the emergence of induced pluripotent stem cells it is now possible to obtain millions of human cells in an ethical manner from adults.  It is possible for us to create microfabricated 3D models and on-chip systems that recapitulate key physiological functions of target organs. These organ-on-a-chip models are turning into indispensable tools to study nanoparticle toxicity, distribution in body-on-a-chip models and translocation across tissue barriers. They provide an opportunity to uncouple and systematically study various factors leading to low bioavailability of nanoparticles in vivo.

This conference will expand upon the mission of its predecessor by providing a diverse and broadened platform to:

  • deepen mechanistic understanding of biodistribution of systematically applied nanoparticles; 
  • explore the effects of mechanical environment;
  • illustrate the use of tissue and organ-on-a-chip models in the studies of nanoparticle distribution and toxicity;
  • generate improved mechanistic understanding of the factors necessary to control in vivo nanoparticle targeting;
  • exploit this understanding to generate highly effective nanotechnologies for the early detection, imaging, and treatment of human diseases.

The conference aims to bring together a broad range of scientists covering the interdisciplinary fields of biology, chemical and bioengineering, material science, physics, and others. Moreover, the conference will devote a dedicated ‘industry session’ where selected companies will have an opportunity to give oral presentations in an effort to bridge academic research and industrial R&D.

Overall, the fourth chapter of this conference series will help to further discussions among the interdisciplinary nanotechnology in medicine community, while also fostering the development of new, synergistic collaborations between academic and industrial scientists.

Conference Organization

Chairs                                             


Prof. Milica Radisic
University of Toronto, Canada
Web page     m.radisic@utoronto.ca

Prof. Victor Shahin         
Institute of Physiology II, Medical Faculty
University of Münster, Germany  
Web page   shahin@uni-muenster.de

Organizing Committee


Millicent Sullivan, PhD
University of Delaware, USA


Josué Sznitman, Dr. Sc.
Technion-Israel Institute of Technology, Israel


 Joye Bramble, PhD
Eisai Pharmaceuticals, USA

Conference Fees

All conference fees are inclusive. They include registration, accommodations (Sunday, Monday, Tuesday, Wednesday and Thursday nights), all meals with the exception of one dinner on your own, excursion, taxes, and gratuities from the reception and dinner on Sunday through breakfast on Friday in a standard room.  Incidental fees (telephone calls, faxes, spa, laundry, etc.) are billed to your personal account by the hotel. 

We will re-open registration in December 2021. 

ALL PARTICIPANTS (INCLUDING MEMBERS OF THE ORGANIZING COMMITTEE AND INVITED SPEAKERS) ARE REQUIRED TO REGISTER.

The conference fees are: 


Register on or before March 31, 2022 
Register after 
March 31, 2022 

Participant (single occupancy or sharing room with a guest; guest fee additional)US $1,725.00 US $1,925.00 
Participant (sharing a room with another participant)US $1,600.00 US 1,800.00
Bona fide Graduate Student (sharing a room with another student) (Those in this category must send proof of current status – copy of current Student ID can be faxed to 1-212-514-6030 or emailed to Kathy@engconfintl.org)US $1185.00 US $1,385.00 
**Fees for Guest/accompanying person sharing bedroom with single occupancy participant. (Includes all conference included meals as well as the conference excursion)US $688.00US $688.00

If you plan to bring children to the conference, please contact ECI (info@engconfintl.org) for pricing.

Conference Registration

You will need a login name and password to register for ECI conferences through our online system. If you have been a recent participant at an ECI conference or have submitted an online application or request for information about an ECI Conference, you may already have an account with us. If you know your login information, please use it. 

If you are not sure whether you already have a login and password, please click on automated password retrieval and enter your e-mail address before creating a new account. If we don’t have a valid email address on file for you, a pop up window will appear stating that no records were found. Click “OK” and then follow the instructions to create a new account. 

If you have any questions or experience any difficulties, please email tressa@engconfintl.org.

Special Notes and Payment Instructions

We suggest that you register as soon as possible to be certain that you will have a hotel room at the conference rate.  Late registrations will be accepted on a space available basis and late registrants may be housed in a nearby hotel. 

All participants are encouraged to register before March 31, 2022.  There is a discounted price for registering before this date.  Hotel space cannot be guaranteed for registrations received after this date.  Your registration is not officially confirmed until we receive payment of the amount due.  ECI reserves the right to cancel your room registration if payment is not received. Your invoice/receipt will automatically be e-mailed upon of receipt of your registration.  Should you need a signed receipt, please contact Kathy Chan (kathy@engconfintl.org).

Because of contractual guarantees made with the hotel for room and meal functions, no shows, late arrivals, missed meals and early departures cannot receive fee adjustments.  If you have a disability and may require accommodation in order to participate fully in this conference, please indicate this when you register. An ECI representative will contact you to discuss your specific needs. If you have special dietary requirements (e.g., vegetarian or a food allergy), please make a note on your registration.  The chef needs to know this information in advance if we are to accommodate you. ECI will attempt to accommodate special requests such as Kosher or Halal meals, but such meals may not be available at all conference sites. The participant must pay any additional costs for special meal requests to ECI.

Payment must be made by credit card (Visa, MasterCard, and Amex), check or money order drawn on a U.S. bank in U.S. dollars, payable to ENGINEERING CONFERENCES INTERNATIONAL. Checks or money orders in any other currencies are NOT ACCEPTABLE.  Payment must be made on the web site except for those who are sending payment by wire transfer or have a purchase order from their company/institution. 

WIRE TRANSFER PAYMENT: If you are planning to make payment by wire transfer, please contact ECI for the bank information. You must add $30 to cover ECI bank charges. Please reference your full name and the conference title.  Either fax a copy of your bank transfer papers to ECI (Fax: +1-212-514-6030) or email a scanned copy to kathy@engconfintl.org. This is very important – otherwise it is extremely difficult to trace your payment and you may not receive a receipt prior to the conference.

Cancellation Policy: Cancellation must be received by ECI in writing at least 28 days prior to the start of the conference in order for a full refund (less a processing fee) to be considered. The ECI auditors require that refunds for all conference cancellations be processed after the conference so that the necessary back-up information (e.g., hotel list of those in-house) can be attached to the refund request and ECI can verify that the hotel has not charged a cancellation fee. 

Cancellation fees:

  • Cancellations received more than 28 days prior to the conference start date are subject to a processing fee of 4% of the total fee, plus any direct expenses incurred by ECI. 
  • Cancellations received 15 – 28 days prior to the conference start date are subject to a $250 cancellation fee plus any direct expenses incurred by ECI. 
  • Cancellations received 8 – 14 days prior to the conference start date are subject to a $500 cancellation fee plus any direct expenses incurred by ECI. 
  • No refunds will be issued for cancellations received less than 7 days prior to the conference start date. 
  • No refunds will be issued due to inclement weather or travel disruptions/cancellations.

Registrations may be transferred without incurring any penalty or cancellation fee.

Denied or delayed visa

If you will need a visa, please apply for it as soon as possible. If a participant is forced to cancel due to a denied or delayed entry visa, ECI will issue a full refund if ECI has been notified of a potential visa issue at least four weeks prior to the conference start date.

Change of payment method

If an attendee who has already paid the conference fee with a credit card requests that the fee be refunded to that card so that it can be paid in a different manner (e.g., charged to an alternate credit card, or paid via check or bank transfer), a processing fee of 4% of the total fee amount will apply.

Disclaimer

It may be necessary for reasons beyond the control of ECI to alter the content and timing of the program or the identity of the speakers. In the unfortunate circumstance that an event is cancelled, ECI is not liable for any costs incurred by participants in connection with their attendance.

Smoking is prohibited at ECI conferences and conference functions.  

Should you have specific questions regarding your registration, please contact Kathy Chan (Kathy@engconfintl.org). 

The Engineering Conferences International conferences calendar and other information can be found on the ECI web site: www.engconfintl.org

Call for Abstracts

The abstracts should be submitted as soon as possible and no later than the deadline noted below.  The abstract should consist of 5 parts:  purpose, method, results, conclusion, and reference.  The abstract should introduce the proposed subject, summarize its contents, explain any unique aspects, and clearly indicate the specific relevance to the themes of the Conference. 

The abstract must be at least half a page in length with a one page maximum.

Choose one or two of the following topical areas where you feel your work best fits:

  • Nanotechnology for next generation therapies
  • Mechanical environment in health and disease
  • Organ-on-a-chip models to enable nanotherapy
  • Nanotechnology in regenerative medicine

Submission deadline is COMING SOON for both oral and poster presentation.

Please prepare your abstract according to this template: doc.

Only a limited number of oral presentation slots are available and thus all submissions for oral sessions

will be considered for both oral and poster presentation.

Abstract link – https://ssl.linklings.net/conferences/NanoMed/

Plenary and Keynote Speakers

Plenary Speakers

Professor Hossam Haick

Hossam Haick is a Full Professor in the Technion – Israel Institute of Technology and an expert in the field of nanotechnology and non-invasive disease diagnosis. He earned his doctorate from the Technion in 2002. Prof. Haick has published more than 220 publications in top-level journals in the field of nanotechnology, advanced/applied materials/chemistry, and medicine; more than ten five book chapters. Additionally, the technologies developed by Prof. Haick and his team have led to the production of more than 42 patents and patent applications – many of which have been licensed to six international companies. Prof. Haick is the cofounder of FeelIT Ltd. and NanoVation-S.G. Ltd. – startup companies aiming to commercialize innovative non-invasive technology for monitoring vital signs in health.

Prof. Haick is the recipient of dozens of prestigious awards and a coordinator of several international consortia, including the FP-7’s LCAOS, EuroNanoMed’s VOLGACORE and Horizon-2020’s SNIFFPHONE, Horizon-2020’s A-Patch, and Horozon-2020’s VOGAS projects. He is also the recipient of more than 80 international honors and prizes for his achievements, including a Knight of the Order of Academic Palms (conferred by the French Government), the Advanced Alexander von Humboldt Research Award, the Changjiang Distinguished Professorship, the IChemE Global Award, the Sanford Kaplan Prize, the Honorary Doctorate (Doctor of Philosophy Honoris Causa) from the University of Haifa, etc. Prof. Haick was included in more than 80 top-rank listings worldwide, including the “MIT Technology Review” list of 35 leading young scientists in the world, the “50 Sharpest Israeli Minds”, the world’s top-100 influential innovators in the Digital Technology by Nominet Trust (London, UK) and the  top-100 influential people in the world by the GOOD Magazine (Los Angeles, USA). Prof. Haick also received the highest teaching awards granted by the Technion, including the “Yanai Prize for Academic Excellence”.

Besides Prof. Haick’s achievements in research, he has had considerable success as a lecturer, as expressed by the many prizes he has received for excellence in teaching. Prof. Haick is the recipient of the “Yanai Prize for Academic Excellence”, which is given for exceptional contribution in teaching and academic education.  In 2014, Prof. Haick designed and developed the first massive open online course (MOOC) in the Technion and is the first person worldwide to do this in two languages: English and Arabic. This MOOC focuses on the fields of nanotechnology, and nanosensors stressing their implications for use in diagnosis and treatment of disease, as well as in personalized medicine. So far, the course has drawn more than 116,000 participants, thus disseminating knowledge about biomedical science and nanotechnology to people in both developed and developing countries, without admissions bureaucracy.

The research interests of Prof. Haick include nano-array devices for screening, diagnosis and monitoring of disease, nanomaterial-based chemical (flexible) sensors, electronic skin, breath analysis, volatile biomarkers, and cell-to-cell communication.

Dr. Roger Kamm

Professor Kamm began his career at Northwestern University earning a degree in Mechanical Engineering. He subsequently earned both a Master’s and a PhD in Mechanical Engineering at MIT. Since 1978, he has been a professor of Mechanical Engineering at MIT. Professor Kamm was one of the founding members of the Biological Engineering department when it was created in 1998.

An overriding objective of the Mechanobiology Lab is to elucidate the fundamental nature of how cells sense and respond to mechanical stimuli, and to employ the principles revealed by these studies to seek new treatments for neurological disease and cancer, and to develop tissue constructs for drug and toxicity screening.

Both experimental and computational approaches are employed in a manner that encourages the constant interplay between the two for purposes of model validation, direct measurement of critical parameters, and identifying new hypotheses to be tested through experiment.

The Kamm research group works on five broad areas: Biological Machines/Microfluidics, Angiogenesis/Vasculogenesis, Neurological Diseases, Cancer, and Simulation and modeling.

Over the past 10 years, the Mechanobiology group has developed various microfluidic platforms for mimicking the three dimensional microenvironment and investigating the role of mechanical stimuli, such as interstitial flow, cyclic strain, and ECM stiffness gradients, on cellular processes including cell migration, angiogenesis, and differentiation.  Recently, they have drawn upon their understanding of mechanobiology to direct the function of multicellular systems. For example, the angiogenesis model was extended to build functional vascular networks in vitro, and stem cells were differentiated into cardiomyocytes through application of strain. As the complexity of synthetic modules is increased towards building biological machines, mechanics will play a more significant role, particularly in the engineering of neurons and myocytes for sensing and actuation. The Mechanobiology group will employ mechanical engineering as a tool to address this complexity while simultaneously extending our understanding of mechanotransduction. 

Formation of new blood vessel from an existing branch, by a regulated process known as angiogenesis, governs vascular patterning in the body and determines the distribution of nutrients and oxygen supply. Angiogenesis has essential roles in development, reproduction and repair but also occurs in tumor formation and in a variety of diseases. The Kamm lab studies the angiogenic process by computational modeling across multiple scale and by in vitro microfluidic experiments that mimics in vivo biophysical and biochemical microenvironment. They have shown that angiogenic endothelial cells seeded in contact with collagen gel can be induced to form nascent angiogenic sprouts in microfluidic that later develop into a vascular network. 

Tumor invasion has received considerable attention as a critical step in metastatic disease for developing new cancer drugs. Current understanding of the role of biophysical and cellular microenvironment in tumor invasion is limited, because of the lack of appropriate in vitro and in vivo models. The Mechanobiology Lab has adapted their previous microfluidic platforms for studying the role of the endothelium on tumor intravasation and the effects of interstitial flow on tumor cell migration, along with the development of new hard plastic devices for commercial transition.

Most recently, the Lab has embarked on modeling various types of neurological disease including ALS and Alzheimer’s disease.  Both models are used to study the fundamental disease processes, with a longer-term aim of providing platforms for drug screening.  These microphysiological systems are of increasing interest to the biotech and pharmaceutical industries and have led to new research projects funded by industry. 

Confirmed Keynote Speakers

Peter Loskill, Fraunhofer IGB, Germany
Adrian Roth, Roche, Basel, Switzerland
Frank Gu, University of Toronto, Canada
Francesca Baldelli Bombelli, Politecnico Milano, Italy
Naomi Matsuura, University of Toronto, Canada
Stefaan De Smedt, School of Pharmacy Ghent University, Belgium
Jochen Guck, Max Planck Institute for the Science of Light, Erlangen, Germany
Shyni Varghese, Duke Biomedical Engineering , USA
Michael Sefton, University of Toronto

Venue Information

Grand Hotel San Michele

Cetraro and Grand Hotel San Michele

Cetraro Marina, a pleasant seaside resort is about two km from the Cetraro Commune of which it is a part.  The ancient Citrarium (name derived from the abundant citrus cultivation in the area) was a center of the Bruzi rising between Paola and Capo Bonifati.  Its coast location offers many interesting boat excursions.

Grand Hotel San Michele

The picturesque Grand Hotel San Michele is situated on the Tyrrhenian Coast, 120 meters above the Mediterranean Sea, with a fantastic view of Calabria’s southern coast.  It offers visitors one of the prettiest locations Southern Italy has to offer and is considered by many to be one of Calabria’s finest hotels.  Its beach (120 meters below the cliffs) is accessible only by a private special elevator.  The hotel has a swimming pool, driving range, tennis court, minigolf, piano bar and billiard room.

The hotel is surrounded by an organic farm that provides the hotel with fresh organic food.  Vegetables, fruits, olive oil, wine, milk, cheese, daily laid eggs, lamb, veal and pork meat, homemade jams and preserves are all produced on San Michele Hotel’s premises.

Grand Hotel San Michele

The acreage upon which the hotel is situated is also a bird sanctuary, where bird lovers from around Italy come to observe migratory patterns.

The maximum number of people that can be hosted in the hotel is about 80; however, there are other hotels in the area and the hotel can arrange pickups.

Transportation

Cetraro (Calabria), Italy

Air: The Lamezia Airport (SUF) is 75 km from the hotel.  The hotel can arrange for pick-ups.  The airport is served by Alitalia, Delta, Lufthansa and many others

Train: The Paola Railway station is about 21 km from the hotel by ItaliaRail.

Auto: Use the Motorway Roma – Caserta Sud – Salarno – Lagonegro Nord – Fondo Valle Noce.  (293 km)

Sponsor Packages

 Sponsor Packages 

Package A: $1,000 

• Name of Company on Sponsor List in Program 
• Company Logo displayed on screen between sessions 

Package B: $2,500 

• Half page ad in program 
• Name of Company on Sponsor List in Program 
• Company Logo displayed on screen between sessions 

Package C: $5,000 

• Full page ad in program 
• Sponsor a Coffee Break 
• Name of Company on Sponsor List in Program 
• Company logo and link on conference website 
• Company Logo displayed on screen between sessions 

Package D: $7,500 

• Sponsor a Scientific Session or Workshop including oral introduction 
• Full page ad in program 
• Name of Company on Sponsor List in Program 
• Company logo and link on conference website 
• Company Logo displayed on screen between sessions 

Package E: $10,000 

• Table of company information (*space limited) 
• Full page ad in program 
• Name of Company on Sponsor List in Program 
• Company logo and link on conference website 
• Company Logo displayed on screen between sessions 

Package F: $20,000 

• Table of company information (*space limited) 
• Company information packet available in attendees’ registration materials 
• Company logo and link on conference website 
• Full page ad in program 
• Company logo displayed on screen between sessions 
• Name of company on sponsor list in program 

Kevin Korpics (kevin@engconfintl.org) (+1-212-514-6760) may be contacted for invoicing and other questions. Please make checks payable to: 

Engineering Conferences International 
Attn: Nanotechnology in Medicine Conference 
32 Broadway, Suite 314 
New York, NY 10004 

Payment can also be made via wire transfer or credit card. 

You must reference your company name and the conference title “Nanotechnology in Medicine” or code (20-AH) so the contribution can be identified. Thank you in advance. 

Please note that none of the sponsor packages include any free or discounted registrations for attendees from sponsor companies.

General Information about ECI

Engineering Conferences International (ECI) is a not-for-profit, global engineering conferences program, originally established in 1962 that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

The format of the conference provides morning and late afternoon or evening sessions in which major presentations are made. Poster sessions will be scheduled for evening discussion as well. Available time is included during the afternoons for ad hoc meetings, informal discussions, and/or recreation. This format is designed to enhance rapport among participants and promote dialogue on the development of the meeting. We believe the conferences have been instrumental in generating ideas and disseminating information to a greater extent than is possible through more conventional forums.

All participants are expected both to attend the entire conference and to contribute actively to the discussions. The recording/photographing of lectures and presentations is forbidden. As ECI conferences take place in an informal atmosphere, casual clothing is the usual attire.

Smoking is prohibited at ECI conferences and conference functions.