Single-Use Technologies V: Building the Future

An ECI Conference Series

March 20-23, 2022
Marseille, France

Register Now

Poster Size: 1 meter W x 1.5 meters H

About This Conference

Single-Use Technologies V: Building the Future is the fifth event of an ECI conference series started in 2015 and unique in its aim – to advance knowledge in the fundamental science and engineering underpinning Single-Use Technology (SUT).

The conference will be a 4-day event (March 20 to 23, 2022) in Marseille, France, and will target 100-120 attendees, face to face. The conference will have speakers and attendees from industry and academia, single-use final product (e.g. bags, assemblies) manufacturers, film/resin manufacturers as well as keynote speakers from the biopharmaceutical industry, experts in polymers/materials science and manufacturers of novel biomedical devices.

The fifth series of this conference will build on the success of the previous three in-person editions and a successful virtual conference held in May 2021. The fifth edition aims to focus on the role of SUT during the pandemic, including lessons learnt in the process, regulatory and technical aspects and how the industry has changed post-pandemic. Other topics will include sustainability and the role of SUT in continuous processing for established and emerging applications, advances in sensors, soft sensors and their integration within SUT, modelling and optimization tools for assessment of SUT in production facilities. 

This conference brings together a multidisciplinary community interested in collaborating openly towards the advancement and adoption of single-use technology in the bioprocessing industry. The organizing committee welcomes the submission of scientific work that is novel and of high quality.

Confirmed Keynote Speaker

Patricia Hughes

Ph.D. FDA/CDER – Office of Product Quality/Office of Pharmaceutical Manufacturing

Patricia F. Hughes received a Ph.D. in Microbiology from Georgetown University and in 2020 assumed the role of Sr. Scientific Advisor in the Office of Pharmaceutical Manufacturing Assessment (OPMA), Office of Product Quality in CDER/FDA. She is currently involved in developing and implementing policies for quality assessments of applications from a microbiology product quality perspective and for the inspection program for biological products.

While at FDA, she also led various teams/branches of scientists responsible for microbiology product quality assessments of BLAs and for pre-license inspections of biological manufacturing facilities. Prior to joining the FDA, Dr. Hughes held various leadership positions in the biotech/pharmaceutical industry in areas of process development of biological products and in pharmaceutical operations. She has been with the FDA for over 20 years.

Hans-Josef Endres

Director of the Institute for Plastics and Circularity, Leibniz University Hannover

Hans-Josef Endres (Prof. Dr.-Ing.) is professor at the Leibniz University Hannover, Faculty of Mechanical Engineering and director of the Institute of Plastics and Circular Economy (IKK). He received his PhD in mechanical engineering from the Ruhr-University Bochum, Germany in 1995. During his career, he has worked in industry (BUCK Werke, ThyssenKrupp) and research institutions (Fraunhofer WKI and Hochschule Hannover). His research areas are (bio-)plastics, (bio-)composites, plastic technology and testing, recycling, circular economy and sustainability assessment.

Conference Organization

Conference Chairs

Magali Barbaroux, Sartorius
Martina Micheletti, University College London

Steering Committee for Single-Use Technologies V

Ruben Carbonell, North Carolina State University

Weibing Ding, GSK

Regine Eibl-Schindler, Zurich University of Applied Sciences

Beth Junker, BioProcess Advantage LLC

Sally Kline, Genentech-Roche

Gary Lye, University College London

Ekta Mahajan, Genentech-Roche

Robert Repetto, Pfizer

Conference Program

Sartorius Post-Conference Technical Visit

Post conference Technical Visit to Sartorius Single-Use Technologies Manufacturing Site

Wednesday afternoon, 23 March 2022

2:00 pm: Leave the InterContinental Hotel Marseille on chartered coach

• Boxed lunch provided by hotel

2:45 pm: Arrive Sartorius Single-Use Technologies Manufacturing Site

• Sartorius is offering a visit of one of its main Single-use technologies manufacturing sites situated close to  Marseille. 
• Profit from this unique opportunity to visit this site to gain first hand insight into Sartorius as a company, their single-use  manufacturing methodologies along with an overview of how recycling is implemented at Sartorius. 

7:00 pm: Arrive back at InterContinental Hotel Marseille

Note: If you are planning to join the tour, please remember to book a post conference night reservation with Kathy Chan. 

Cost of Visit: No cost, visit of Sartorius.

To register: You can book your seat for the visit when you register for the conference.  If you already registered for the conference, please contact Kathy Chan.

Session Description

Session 1 – Single-use in pandemic times – lessons learnt and future outlook

Co-chairs: Yvonne Genzel (Max Planck Institute), Ekta Mahajan (Roche Genentech), Jeff Carter (Cytiva)

This session accepts papers on the impact of the pandemic on the SUT world, with both a retrospective view to gain lessons learnt, and a prospective view to how the industry may be better prepared for a subsequent major upset.  The session aims to address topics that are central to managing SUT, such as maintaining industry flexible standards, addressing benefits of standardization, and implementing cost-effective risk-mitigation solutions to secure future SUT supply, all while continuing to meet global regulatory requirements. Case studies are welcome on the role of SUT in manufacturing of key therapeutics and vaccines during the pandemic. These case studies may highlight how these technologies have enabled rapid vaccine manufacturing response, as well as the challenges encountered e.g., due to supply constraints. Papers are invited which reflect on post-pandemic world solutions to ensure productivity and to build capacity at speed, while looking forward to anticipating future major industry-changing disruptions and novel risk mitigation strategies to support increase in demand without negative implications to the industry.

Session 2 – Sensors and their integration with single-use technology

Co-Chairs:  Torsten Mayr (TU Graz) and Jim Furey (PendoTECH)

Sensors are critical to biopharmaceutical manufacturing for process control, data acquisition, PAT continuous processing that leads to a more efficient manufacturing processes. Single use processes require sensors that are pre-sterilized, ready to use without any calibration and can be disposed of after the process. Ideally, these sensors are suitable for batch and continuous processes. The scope of this session is to give insights in new developments and advances of sensors for single-use, efforts towards integration in single-use devices, new parameters, miniaturisations, soft sensors, reliability, robustness, and validation approaches for use in a GMP process.

Session 3 – Single-Use advantages in continuous and connected processing

Co-chairs: Catherine Piton (Pall Biotech) and Mark Brower (Merck)

This session will address how SUT have facilitated and supported the development of continuous operation processes for biopharmaceuticals production. Focus areas will include:

• The economic case for SUT in continuous processing, for both upstream and downstream operations and end-to-end processing
• Regulatory and validation considerations and challenges for SUT in continuous processes
• Consideration of ICH Guidelines on Continuous Manufacturing to accommodate large molecules
• Innovative solutions in SUT for continuous processes
• Scale-down approaches for SUT continuous processes 
• How connected is connected and how continuous is continuous?

Session 4 – Single-use adoption in emerging applications

Co-chairs: Qasim Rafiq (UCL) and Diego Schmidhalter (Lonza)

This session will focus on the use of single-use technologies in bioprocesses for emerging applications, including vaccines, cell and gene therapy, industrial biotechnology and antibody-drug conjugates. The session will include case studies showcasing the adoption and application of single-use technologies across these bioprocessing sectors, with a focus on the challenges and opportunities associated with their integration. In some instances, these sectors rely exclusively on single-use technologies (e.g. patient-specific gene therapies), and this session will highlight how single-use technology can accelerate the quest for speed and flexibility in this space. This session will provide an evaluation of how single-use technologies have been implemented, with a specific focus on upstream/downstream process unit operations and end-to-end bioprocessing. It will also explore the future requirements and perspectives to ensure successful integration of single-use technologies for the manufacture of 21st century biological products.

Session 5 – Single use and sustainability

Co-chairs : Kristi Budzinski (Roche Genentech) and Nelly Montenay (Sartorius)

This session will focus on the integration of environmental sustainability priorities into Single Use Technologies from the design phase through the end-of-life. It will include case studies on a SUS bioprocess environmental assessment with tools such as LCA (Life Cycle Assessment, but not limited to) polymer resin choice and assembly design as well as end-of-life treatment options. Environmental hot spots will be identified through these assessments and then the session will focus on opportunities in these areas to reduce impact. The session will explore design choices such as polymer formulation, product functionality and design to integrate sustainable criteria in SUT development. Reusability options and shelf-life extension during the use phase will be discussed as opportunities to reduce impact. It will also explore end of life management options and the challenge of segregating packaging, and non-contaminated versus contaminated components.

Poster Award Competition Winners

March 20-23, Marseille, France

1^st Prize:

Fanny Gaston and Melanie Gauthier
Sartorius, France
“Standardization of visible particles measurement in single-use systems,an advantage for the emerging applications”

2^nd Prize:

Julien Muzard
Entegris, France
“High-cell density cryopreservation strategy”

3^rd Prize (Tie):

Jacalyn Saint Rudolph
Emerson, USA
“Design verification testing methodology for a new Rosemount pH sensor”

Kevin Viebrock
University of Braunschweig, Germany
“Bioprocess characterization at the micro-scale: Optical sensor integration in a novel capillary-wave micro-bioreactor”

Call for Abstracts

One-page abstracts should be submitted as soon as possible and no later than the deadlines noted below. The abstract should include both the significance of the research as well as results that will be discussed in order to allow a scientific assessment of the work by the organizers. Please indicate the most relevant session topic for which you are submitting your abstract and whether the abstract should be considered for an oral or poster presentation.

The specific topics are (sessions are described above):

Session 1 – Single-use in pandemic times – lessons learnt and future outlook

Session 2 – Sensors and their integration with single-use technology

Session 3 – Single-Use advantages in continuous and connected processing

Session 4 – Single-use adoption in emerging applications

Session 5 – Single use and sustainability

Only a limited number of oral presentation slots are available. Thus all submissions for oral sessions will be considered for both oral and poster presentation.

Poster Size: 1 meter W x 1.5 meters H

All abstracts should be submitted electronically and submissions must follow the template provided at this link.

Deadline for abstracts for oral presentations:  Closed
Poster abstract due date: February 28, 2022

Awards will be presented for the best overall poster and the top student poster.

https://ssl.linklings.net/conferences/singleusetech/

Please prepare your abstract according to this template: docx or doc.

Conference Fees

All conference fees are inclusive. They include registration, accommodations (Sunday, Monday, and Tuesday  nights), all meals excursion, taxes, and gratuities from the reception and dinner on Sunday through lunch on Wednesday in a standard room.  Incidental fees (telephone calls, parking, faxes, spa, laundry, etc.) are billed to your personal account by the hotel.  

ALL PARTICIPANTS (INCLUDING MEMBERS OF THE ORGANIZING COMMITTEE AND INVITED SPEAKERS) ARE REQUIRED TO REGISTER.

The conference fees are: 

	Register on or before March 10, 2022	Register after March 10, 2022
Participant (single occupancy or sharing room with a guest; guest fee additional)	US $2725.00	US $2925.00
Participant (sharing a room with another participant)	US $2380.00	US $2580.00
Bona fide Graduate Student (sharing a room with another student) (Those in this category must send proof of current status – copy of current Student ID can be faxed to 1-212-514-6030 or emailed to Kathy@engconfintl.org)	US $1965.00	US $2165.00
**Fees for Guest/accompanying person sharing bedroom with single occupancy participant. (Includes all conference included meals as well as the conference excursion)	US $1180.00	US $1180.00

If you plan to bring children to the conference, please contact ECI (info@engconfintl.org) for pricing.

Conference Registration

You will need a login name and password to register for ECI conferences through our online system. If you have been a recent participant at an ECI conference or have submitted an online application or request for information about an ECI Conference, you may already have an account with us. If you know your login information, please use it. 

If you are not sure whether you already have a login and password, please click on automated password retrieval and enter your e-mail address before creating a new account. If we don’t have a valid email address on file for you, a pop up window will appear stating that no records were found. Click “OK” and then follow the instructions to create a new account. 

If you have any questions or experience any difficulties, please email tressa@engconfintl.org.

Special Notes and Payment Instructions

We suggest that you register as soon as possible to be certain that you will have a hotel room at the conference rate.  Late registrations will be accepted on a space available basis and late registrants may be housed in a nearby hotel. 

All participants are encouraged to register before March 5, 2022.  There is a discounted price for registering before this date.  Hotel space cannot be guaranteed for registrations received after this date.  Your registration is not officially confirmed until we receive payment of the amount due.  ECI reserves the right to cancel your room registration if payment is not received. Your invoice/receipt will automatically be e-mailed upon of receipt of your registration.  Should you need a signed receipt, please contact Kathy Chan.

Because of contractual guarantees made with the hotel for room and meal functions, no shows, late arrivals, missed meals and early departures cannot receive fee adjustments.  If you have a disability and may require accommodation in order to participate fully in this conference, please indicate this when you register. An ECI representative will contact you to discuss your specific needs. If you have special dietary requirements (e.g., vegetarian or a food allergy), please make a note on your registration.  The chef needs to know this information in advance if we are to accommodate you. ECI will attempt to accommodate special requests such as Kosher or Halal meals, but such meals may not be available at all conference sites. The participant must pay any additional costs for special meal requests to ECI.

Payment must be made by credit card (Visa, MasterCard, and Amex), check or money order drawn on a U.S. bank in U.S. dollars, payable to ENGINEERING CONFERENCES INTERNATIONAL. Checks or money orders in any other currencies are NOT ACCEPTABLE.  Payment must be made on the web site except for those who are sending payment by wire transfer or have a purchase order from their company/institution. 

WIRE TRANSFER PAYMENT: If you are planning to make payment by wire transfer, please contact ECI for the bank information. You must add $30 to cover ECI bank charges. Please reference your full name and the conference title.  Either fax a copy of your bank transfer papers to ECI (Fax: +1-212-514-6030) or email a scanned copy to kathy@engconfintl.org.  This is very important – otherwise it is extremely difficult to trace your payment and you may not receive a receipt prior to the conference.

Cancellation Policy: Cancellation must be received by ECI in writing at least 28 days prior to the start of the conference in order for a full refund (less a processing fee) to be considered. The ECI auditors require that refunds for all conference cancellations be processed after the conference so that the necessary back-up information (e.g., hotel list of those in-house) can be attached to the refund request and ECI can verify that the hotel has not charged a cancellation fee. 

Cancellation fees:

• Cancellations received more than 28 days prior to the conference start date are subject to a processing fee of 4% of the total fee, plus any direct expenses incurred by ECI. 
• Cancellations received 15 – 28 days prior to the conference start date are subject to a $250 cancellation fee plus any direct expenses incurred by ECI. 
• Cancellations received 8 – 14 days prior to the conference start date are subject to a $500 cancellation fee plus any direct expenses incurred by ECI. 
• No refunds will be issued for cancellations received less than 7 days prior to the conference start date. 
• No refunds will be issued due to inclement weather or travel disruptions/cancellations.

Registrations may be transferred without incurring any penalty or cancellation fee.

Denied or delayed visa

If you will need a visa, please apply for it as soon as possible. If a participant is forced to cancel due to a denied or delayed entry visa, ECI will issue a full refund if ECI has been notified of a potential visa issue at least four weeks prior to the conference start date.

Change of payment method

If an attendee who has already paid the conference fee with a credit card requests that the fee be refunded to that card so that it can be paid in a different manner (e.g., charged to an alternate credit card, or paid via check or bank transfer), a processing fee of 4% of the total fee amount will apply.

Disclaimer

It may be necessary for reasons beyond the control of ECI to alter the content and timing of the program or the identity of the speakers. In the unfortunate circumstance that an event is cancelled, ECI is not liable for any costs incurred by participants in connection with their attendance.

Smoking is prohibited at ECI conferences and conference functions.  
Should you have specific questions regarding your registration, please contact Kathy Chan.

Sponsors

Venue Information

Marseille

Marseille is the oldest city in France. A Greek settlement, founded in the 7^th century BC, then called Massilia, Marseille was seized by the Romans in 49 BC.  It became the “Gateway to the West” for most Oriental trade. France’s largest port and lively second largest city has close links with the Middle East and North Africa.  It claims 300 days of sunshine per year.

Narrow stepped streets, quiet squares, and fine 18^th century facades contrast with the bustle of Boulevard Canebiére and the Cité Radieuse, Le Corbusier’s postwar radical housing complex.  The old harbor now only handles small boats, but its daily fish market is renowned. The intense smell of fish and salty sea air contribute to making this experience engaging to the senses.  Large cruise ships dock at Léon Gourret Pier, approximately five kilometers north.

The defining symbol of Marseille towers on a hilltop 154 meters above the city, with the gilded statue of the Virgin Mary stretching skywards.  The views are simply stunning. One can either take a shuttle for convenience or embark on a just-under-an-hour-long hike up from the old port.  

Saint Victor Abbey is Marseille’s oldest church.  The abbey was built by the graves of Marseille’s first martyrs.  Throughout history, the building was used as a church, prison, warehouse and barracks.

Marseille has many excellent museums.  Those in the old harbor include the Roman Docks Museum, situated on the site of a Roman docks warehouse discovered after World War II.  It contains a range of impressive artefacts discovered during the reconstruction of the Old Harbor. One of its primary attractions are the “dolia” – large ceramic containers once used to store oils and wines.  

The Marseille History Museum is an interesting and well-visited museum with historical and archeological artefacts dating back to the city’s founding times.   The Palais Longchamp is an extraordinary, majestic building right in the middle of the city that takes you years back in time with its ornamental staircases and large fountains.  The building houses the Musée des Beaux-Arts and the Natural History Museum.

Splendidly situated on a hillside above the Vieux Port, this colorful neighborhood is the historic center and cultural heart of Marseille. Le Panier is Marseille’s oldest quarter, inhabited since antiquity when the ancient Greeks settled here in 600 BC. With its steep, narrow winding streets and quaint pastel buildings, this quarter offers a glimpse into the charming personality of Marseilles. Once a working class neighborhood, Le Panier is now gentrified, but still has a fascinating multiethnic and artistic character. You will find plenty of authentic Algerian cuisine, local artisan boutiques, gourmet food shops, and art galleries. This quarter is also a residential neighborhood, and the typical houses with shuttered window and lines of laundry provide evidence of the families who live there.

The Marseille Tourism website, www.marseille-tourisme.com/en/, provides a wealth of information about this vibrant city and it is highly recommended that you check it out.

InterContinental Marseille – Hotel Dieu

Housed in a listed historical monument, having served as the city’s primary hospital for over eight hundred years, this elegant hotel opened in 2013.  Offering an inimitable view of Marseille, the InterContinental Marseille-Hotel Dieu, is a most majestic encounter with the city and Provence. It is perfectly located, overlooking the Vieux Port, right beside the oldest district in Marseille known as the Panier.  The hotel boasts a very beautiful terrace from which one can admire the Vieux Port.  

The remains of a 12th century chapel are buried beneath the hotel’s gardens. A Roman mosaic dating from the 1st century A.D. can be seen in the Espace Culturel (on the ground floor).  A sustainable pilot project, the InterContinental Marseille – Hotel Dieu is the first hotel ever to be restructured subject to an environmental quality certification. This certification requires scrupulous monitoring of stringent specifications, especially in the choice of building materials, energy and water management, visual comfort, acoustics, and in the quality of air and water.

Pre and Post Conference Reservation

Your registration includes accommodations for the conference period (nights of Sunday, March 20; Monday, March 21; and Tuesday, March 22).  If you are arriving before March 20 or staying after the conference, please contact Kathy Chan to book it.  The room rate is

• Single “run of the house” room BB:  $275 after tax per night
• Double “run of the house” room BB: $300 after tax per night 

Pre Conference nights:  Thursday, March 17; Friday, March 18, Saturday, March 19

Post Conference nights:  Wednesday, March 23; Thursday, March 24; Friday, March 25 (checking out on Saturday, March 26)

Note: Pre/Post night reservations are based upon hotel’s availability.  Cancellation policy is 9 days prior to arrival.

Sponsor Information

 Package A: $2,500 

• Half-page ad in program 
• Name of Company on Sponsor List in Program 
• Company Logo displayed on screen between sessions 

Package B: $5,000 

• Full page ad in program 
• Sponsor a Coffee Break including poster display 
• Name of Company on Sponsor List in Program 
• Company logo & link on conference website 
• Company Logo displayed on screen between sessions 

Package C: $7,500 

• Sponsor a Scientific Session or Workshop 
• Full page ad in program 
• Name of Company on Sponsor List in Program 
• Company logo & link on conference website 
• Company Logo displayed on screen between sessions 

Package D: $10,000 

• Full page ad in program 
• Company information packet available in attendees’ registration materials 
• Name of Company on Sponsor List in Program 
• Company logo & link on conference website 
• Company Logo displayed on screen between sessions 

Kevin Korpics (kevin@engconfintl.org) (+1-212-514-6760) may be contacted for invoicing and other questions. Please make checks payable to: 

Engineering Conferences International 
Attn: Single Use Technology III Conference 
32 Broadway, Suite 314 
New York, NY 10004 

Payment can also be made via wire transfer or credit card. 

You must reference your company name and the conference title “Single Use Technology IV” or code (20-AS) so the contribution can be identified. Thank you in advance. 

Please note that none of the sponsor packages include any free or discounted registrations for attendees from sponsor companies.

Previous Conferences in This Series

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications
October 18-21, 2015
Leesburg, VA, USA
Conference Chairs:
Ekta Mahajan, Genentech, Inc., USA
Gary Lye, Department of Biochemical Engineering, University College London, UK

Single-Use Technologies II: Bridging Polymer Science to Biotechnology Applications 
May 7-10, 2017
Tomar, Portugal
Conference Chairs:
Ekta Mahajan, Genentech, Inc., USA
Gary Lye, Department of Biochemical Engineering, University College London, UK
Regine Eibl, Zurich University of Applied Science, Switzerland

Single-Use Technologies III: Scientific and Technical Advancements
September 23-26, 2018
Snowbird, Utah, USA
Conference Chairs:
Weibing Ding, Amgen, USA
Martina Micheletti, University College London, UK
Robert Repetto, Pfizer, USA

Single-Use Technologies IV: Building the Future Webinar
May 20, May 25, June 1, 2021
Conference Chairs:
Magali Barbaroux, Sartorius, France;
Weibing Ding, GSK
Martina Micheletti, University College London

General Information about ECI

Engineering Conferences International (ECI) is a not-for-profit, global engineering conferences program, originally established in 1962 that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

The format of the conference provides morning and late afternoon or evening sessions in which major presentations are made. Poster sessions will be scheduled for evening discussion as well. Available time is included during the afternoons for ad hoc meetings, informal discussions, and/or recreation. This format is designed to enhance rapport among participants and promote dialogue on the development of the meeting. We believe the conferences have been instrumental in generating ideas and disseminating information to a greater extent than is possible through more conventional forums.

All participants are expected both to attend the entire conference and to contribute actively to the discussions. The recording/photographing of lectures and presentations is forbidden. As ECI conferences take place in an informal atmosphere, casual clothing is the usual attire.

Smoking is prohibited at ECI conferences and conference functions.

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